The linear ubiquitin chain assembly complex LUBAC generates heterotypic ubiquitin chains
نویسندگان
چکیده
منابع مشابه
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
The linear ubiquitin chain assembly complex (LUBAC) is a RING E3 ligase that regulates immune and inflammatory signalling pathways. Unlike classical RING E3 ligases, LUBAC determines the type of ubiquitin chain being formed, an activity normally associated with the E2 enzyme. We show that the RING-in-between-RING (RBR)-containing region of HOIP--the catalytic subunit of LUBAC--is sufficient to ...
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ژورنال
عنوان ژورنال: eLife
سال: 2021
ISSN: 2050-084X
DOI: 10.7554/elife.60660